Tomato hypersensitivity in peach allergic patients: rPru p3 and rPru p1 positivity is predictive of the symptom severity

Methods within a population of patients with different grades of OAS for peach (mild-OAS, group A; and severe systemic symptoms to peach, group B) we selected patients with documented allergic reactions to tomato. We investigated the type of reaction to tomato by means of a clinical questionnaire, skin prick tests, prick + prick with fresh tomato and anti-rPru p 1, 3, 4, anti-rBet v 1, 2 and 4 IgE specific measurements. We compared the kind of clinical reactions to tomato between group A and group B patients. Statistical analyses were carried out with parametric and non parametric tests to examine the relationship between anti-rPru p 1 and 3 IgE levels and symptom severity. Results patients with severe symptoms to peach (group B) were at major risk of presenting severe symptoms to tomato (p=0.017). We investigated this correlation and found that patients with systemic severe symptoms to tomato presented higher specific IgE levels to rPru p 3 than patients with mild OAS (p= 0.0291). On the contrary patients with mild OAS to tomato presented higher rPru p 1 specific IgE levels than patients with severe systemic symptoms (p=0.047).